https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Reactive astrogliosis in the era of single-cell transcriptomics https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:52762 Wed 28 Feb 2024 16:23:26 AEDT ]]> Anti-RAGE antibody selectively blocks acute systemic inflammatory responses to LPS in serum, liver, CSF and striatum https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:34315 Wed 27 Feb 2019 12:25:36 AEDT ]]> Astrocyte activation in neurovascular damage and repair following ischaemic stroke https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:45205 Wed 26 Oct 2022 14:39:16 AEDT ]]> Chronic stress induced disruption of the peri-infarct neurovascular unit following experimentally induced photothrombotic stroke https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:32497 Wed 17 Nov 2021 16:32:12 AEDT ]]> C3 deficiency ameliorates the negative effects of irradiation of the young brain on hippocampal development and learning https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:30287 Wed 11 Apr 2018 12:31:05 AEST ]]> Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:53700 Wed 10 Jan 2024 10:48:50 AEDT ]]> Investigating the processes of age-related inflammation in the central nervous system https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:40064 Wed 06 Mar 2024 15:05:45 AEDT ]]> More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:43876 Tue 04 Oct 2022 12:35:43 AEDT ]]> The copper bis(thiosemicarbazone) complex CuII(atsm) is protective against cerebral ischemia through modulation of the inflammatory milieu https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:34330 bis(thiosemicarbazone) complex, CuII (atsm), is beneficial in acute brain injury, in preclinical mouse models of ischemic stroke. We demonstrate that the copper complex CuII (atsm) protects neurons from excitotoxicity and N2a cells from OGD in vitro, and is protective in permanent and transient ischemia models in mice as measured by functional outcome and lesion size. Copper delivery in the ischemic brains modulates the inflammatory response, specifically affecting the myeloid cells. It reduces CD45 and Iba1 immunoreactivity, and alters the morphology of Iba1 positive cells in the ischemic brain. CuII(atsm) also protects endogenous microglia against ischemic insult and reduces the proportion of invading monocytes. These results demonstrate that the copper complex CuII(atsm) is an inflammation-modulating compound with high therapeutic potential in stroke and is a strong candidate for the development of therapies for acute brain injury.]]> Thu 17 Mar 2022 14:35:40 AEDT ]]> Peripheral immune cells infiltrate into sites of secondary neurodegeneration after ischemic stroke https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:37014 LO and Ly6G⁻Ly6CHI monocytes. Our results indicate that infiltrating immune cells persist in ischemic tissue after the acute ischemic phase, and are increased in sites of SND. Importantly, immune cells have been shown to play pivotal roles in both damage and repair processes after stroke. Our findings indicate that immune cells may also be involved in the pathogenesis of SND and further clinical studies are warranted to characterise the nature of inflammatory cell infiltrates in human disease.]]> Thu 17 Feb 2022 09:29:32 AEDT ]]> Characterization of physiological and neural alterations in chlamydial reproductive tract infection https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:56161 Thu 08 Aug 2024 14:33:00 AEST ]]> Model perturbations of glial synaptomodulatory and immune functions https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:36432 Sun 03 May 2020 16:20:21 AEST ]]> Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:10881 Sat 24 Mar 2018 08:11:33 AEDT ]]> A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: do these drugs possess anti-inflammatory properties and how relevant is this in the treatment of depression? https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:19925 Sat 24 Mar 2018 08:03:47 AEDT ]]> Acute and chronic stress-induced disturbances of microglial plasticity, phenotype and function https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:19926 Sat 24 Mar 2018 08:03:47 AEDT ]]> Calorie restriction increases lipopolysaccharide-induced neuropeptide Y immunolabeling and reduces microglial cell area in the arcuate hypothalamic nucleus. https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:20260 Sat 24 Mar 2018 07:59:55 AEDT ]]> 'Neuroinflammation' differs categorically from inflammation: transcriptomes of Alzheimer's disease, Parkinson's disease, schizophrenia and inflammatory diseases compared https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:21125 Sat 24 Mar 2018 07:53:55 AEDT ]]> Phagocytosis executes delayed neuronal death after focal brain ischemia https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:28633 Sat 24 Mar 2018 07:38:53 AEDT ]]> Prior voluntary wheel running attenuates neuropathic pain https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:25827 Sat 24 Mar 2018 07:34:39 AEDT ]]> Amyloid β induces microglia to phagocytose neurons via activation of protein kinase Cs and NADPH oxidase https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:25871 Sat 24 Mar 2018 07:25:52 AEDT ]]> Cognitive deficits develop 1 month after diffuse brain injury and are exaggerated by microglia-associated reactivity to peripheral immune challenge https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:24405 Sat 24 Mar 2018 07:14:23 AEDT ]]> Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:24954 KO astrocytes did not augment transforming growth factor β after immune challenge and failed to resolve microglial activation. Collectively, a major cytokine-regulatory loop between activated microglia and astrocytes is impaired in the aged brain.]]> Sat 24 Mar 2018 07:14:18 AEDT ]]> An examination of how environmental disturbances alter microglia morphology and function within the CNS https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:27548 Mon 23 Sep 2019 11:05:13 AEST ]]> The role of early versus late gestational maternal immune activation in the aetiology of schizophrenia: establishing a rat model with a focus on cognitive symptomology and neuroinflammation https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:32284 Mon 23 Sep 2019 10:58:58 AEST ]]> Neuroepidemiology of traumatic brain injury https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:31994 Mon 17 Dec 2018 14:02:45 AEDT ]]> Alzheimer's disease-like perturbations in HIV-mediated neuronal dysfunctions: understanding mechanisms and developing therapeutic strategies https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:38563 Mon 09 May 2022 16:16:35 AEST ]]> Abrogation of type-I interferon signalling alters the microglial response to Aß<sub>1-42</sub> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:44488 1–42 exposure increases bioactive levels of type-I IFN produced by primary microglia alongside increased expression of type-I IFN related genes. Primary microglia isolated from brains of APPswePS1ΔE9 mice with ablated type-I IFN signalling show an increased phagocytic ability to uptake FITC-Aβ1–42. Correlative assessment of plaque sizes in aged APPswePS1ΔE9 mice with abrogated type-I IFN signalling show unchanged deposition levels. Microglia from these mice did however show alterations in morphology. This data further highlights the role of type-I IFN signalling within microglia and identifies a role in phagocytosis. As such, targeting both microglial and global type-I IFN signalling presents as a novel therapeutic strategy for AD management.]]> Fri 14 Oct 2022 09:11:35 AEDT ]]>